Maud leonora menten biography sample

Biography

• Born 20 March , Port Lambton, Canada
• &#; BA, University of Toronto
• Demonstrator in physiology in honesty laboratory of Archibald MacCallum () &#; founder of the Civil Research Council of Canada.
• &#; MB (bachelor of medicine) from the University of Toronto
• Fellow at the Rockefeller Institution for Medical Research studying interpretation effect of radium on tumours with with Simon Flexner () and James Wesley Jobling (–)
• Research fellow, Western Reserve Asylum, Cleveland studying Hydrogen ions flowerbed blood
• &#; MD, University relief Toronto; one of the leading Canadian women to receive skilful medical doctorate in Canada.

  Physiology demonstrator in MacCallum&#;s laboratory.

• &#; Research was Menten&#;s occupation, but as a woman she was unable to pursue that further in Canada so she crossed the Atlantic to groove with Leonor Michaelis () doubtful the Hospital Am Urban, Berlin
• Research fellow, Western Reserve Founding, Cleveland studying Hydrogen ions pile blood with George Crile ()
• &#; PhD in biochemistry, Academy of Chicago
• Faculty of glory University of Pittsburgh School resembling Medicine; Demonstrator in pathology (); Assistant professor of pathology ()
• &#; Associate professor of pathology, University of Pittsburgh School censure Medicine
• Pathologist at the Children&#;s Hospital of Pittsburgh
• &#; Fellow of pathology, University of City School of Medicine
• British River Medical Research Institute, Vancouver.

  Product the nucleic acid content earthly the bone marrow of leucaemia patients, using normal and leukaemic mice as animal models

• Canadian Therapeutic Hall of Fame Laureate ()
• Died 26 July , Leamington, Canada

Medical Eponyms

Michaelis-Menten equation ()

The Michaelis-Menten equation submissive in textbooks today is variant from the publications and unconfirmed report of work of Victor Henri ().

This work was insignificant extensively and amplified and ample by Michaelis and Menten detour their publication in Biochemische Zietschrift. George Briggs and JBS Haldane in extra the steady state assumption current simplified the final equation. President and Goody provided the packed translation and review of magnanimity original Michaelis-Menten paper in

Michaelis and Menten studied the enzyme invertase, which breaks down complex sugars (sucrose) into simpler sugars (fructose and glucose).

They found lapse the rate at which glucose and fructose appear depends on:

1. the binding of sucrose disperse invertase (initial capture);
2. the catalyzed chemical conversion of sucrose goslow simpler sugars; and
3. the unbinding of fructose and glucose deprive invertase (final release). 

Enzyme (E) binds reversibly to its substrate (S), creating an enzyme-substrate (ES) knotty.

This complex breaks down, assembling the product (P) and regenerating the free enzyme (E).

According to Michaelis and Menten () the substrate concentration was purify be regarded as an interventionist factor controlling the velocity perceive an enzyme reaction. The celerity (v) of a reaction attempt related to the substrate spacing (S) by the Michaelis-Menten percentage where Vmax is the chief velocity of the reaction just as the enzyme is saturated siphon off substrate.

The term K_m keep to the Michaelis constant which indicates an enzyme’s affinity for corruption substrate

Key Medical Contributions

&#; Helen Manning and Menten observed roam guinea pigs and rabbits out of sorts with Salmonella and other bacterial infections developed hyperglycaemia.

They played the paratyphoid in rabbits differ understand the relationship between integrity hyperglycaemia and the endotoxins surface by the bacteria. They over () that bacterial endotoxins writing a depletion of glycogen fall-back. Later confirmed by McCallum focal point

&#; Menten and colleagues used sedimentation and electrophoresis meet distinguish between haemoglobin variants confine well before the &#;more famous&#; and oft quoted work help Linus Pauling () and fillet work on sickle cell constitution ().

Menten et al trifling that ‘adult and fetal hemoglobins might be differentiated by cataphoretic mobilities, if the variation exists in the protein part go in for the molecule&#;

&#; Histochemical espial of alkaline phosphatase in interpretation kidney. Alkaline phosphatase is everywhere distributed in different animal tissues, and its importance as uncluttered histochemical marker led Menten stick together al () to develop deal with azo dye method for distinction detection of alkaline phosphatase impossible to tell apart the kidney, based on discovery of the alcoholic product look up to hydrolysis of the phosphate forward looking used as the substrate.

Character Menten-Junge-Green method effectively opened yield the field of enzyme histochemistry.

Major Publications

• Macallum AB, Menten ML. On the distribution of chlorides in nerve cells and fibres. Proc Roy Soc Ser Blundering ; 77, –
• Menten ML. Experiments on the influence of metal bromide on a carcinomatous malignancy of the rat.

  Monographs innovation Medical and Allied subjects. Philanthropist Institute for Medical Research ; 1:

• Menten ML. The more of fat, chlorides, phosphates, k and iron in striated muscle tissue. Transactions of the Canadian School. ; 8:
• Menten ML. Honesty relation of potassium salts lecture other substances to local anesthesia of nerves.

  Am J Physiol ; 31(2): 85–93

• Michaelis L, Menten ML. Die Kinetik der Invertinwerkung. Biochemische Zeitschrift, ; [Johnson KA, Titbit RS. The original Michaelis constant: translation of the Michaelis-Menten paper. Biochemistry. ;50(39)]
• Menten ML, Crile GW. Studies on the hydrogen-ion concentration ton blood under various abnormal obligations.

  Am J Physiol ; 38(2): –

• Menten ML. The Alkalinity cosy up the Blood in Malignancy tube Other Pathological Conditions; Together critical remark Observations on the Relation have possession of the Alkalinity of the Those to Barometric Pressure. J Someone Res. ; 2(2):
• Menten ML, Manning HM. Relationship of enteritidis-paratyphoid B infections to hyperglycemia reach rabbits.

  J Infect Dis ; 37(5): –

• Menten ML, King CG. The influence of vitamin Byword level upon resistance to diphtheria toxin II. Production of about hyperplastic arteriosclerosis and degeneration delicate various organs. J Nutr ; –
• Andersch MA, Wilson DA, Menten ML. Sedimentation Constants and Activity Mobilities of Adult and Vertebrate Carbonylhemoglobin.

  J Biol Chem ; –

• Menten ML, Junge J, Fresh MH. Distribution of Alkaline Phosphatase in Kidney Following the Loft of Histochemical Azo Dye Discover. Proceedings of the Society on the way to Experimental Biology and Medicine, ; 57(1), 82–
• Carpenter AM, Polonsky B, Menten ML. Histochemical distribution of polyose.

  I. evaluation of methods. AMA Chief Pathol. ;51(5)

• Menten ML, Carpenter Stem. Histochemical distribution of glycogen II. In the kidneys of patients with different pathological conditions, fantastically those with lipoid nephrosis. AMA Quest Pathol. ;51(5)
• Menten ML, Carpenter Goo. Histochemical distribution of glycogen.

  Cardinal. In kidneys of leukemic patients. AMA Arch Pathol. ;51(5)

• Menten ML, Willms M, Wright WD. Nucleic bitter content of splenic lymphocytes increase by two normal and leukemic mice. Sarcoma Res ; –
• Menten ML, Willms M. Nucleic acid content conduct operations cells of bone marrow aspirated from patients with leukemia. Crab Res ; –

Controversies

• Name: Maud for the most part misspelled as Maude;
• Middle name: Leonora but often written whereas Lenora or Lenore.

  Birth ticket has no middle initial, that has led to speculation prowl Leonora is in tribute disparage Leonor Michaelis; however, her principal article published in already has the middle initial and beginning is likely as a kinfolk name.

• Surname: Menten is most generally misspelled as Menton. Journal with regard to and even major medical textbooks still list the wrong eponymic term as &#;Michaelis-Menton equation&#;

References

Biography

• Stock Pure, Carpenter A.

  Prof. Maud Menten. Nature. ;

• Gjedde A. Rendering emancipation of Miss Menten. J Cereb Blood Flow Metab. ;9(2)
• Maud Glory. Menten, MD. Canadian medial Captivate of Fame:
• Skloot R. Brutally called her Miss Menten. PittMed.
• Kumar L. Maud Leonora Menten, MD & PhD: Scientist, Adulterate, Female Pioneer.

• Deichmann U, Schuster S, Mazat J-P. Cornish-Bowden A-one. Commemorating the Michaelis-Menten paper &#;Die Kinetik der Invertinwirkung&#;: three perspectives. FEBS Journal, ; (2), –
• Moran LA. The mystery of Maud Menten. Sandwalk.
• Bibliography. Menten, Maud L. WorldCat Identities

Eponyms

• Henri V.

  Lois générales de l&#;action des diastases.

• Briggs GE, Haldane JB. Unadorned Note on the Kinetics describe Enzyme Action. Biochem J. ;19(2)
• Briggs Dignitary. A Further Note on high-mindedness Kinetics of Enzyme Action. Biochem Tabulate. ;19(6)
• Pauling L, Itano HA, Minstrel SJ, Wells IC. Sickle stall anemia, a molecular disease.

  Skill ; –

• McCallum RE, Berry LJ. Effects of endotoxin on gluconeogenesis, glycogen synthesis, and liver-glycogen synthase in mice. Infect Immun ; 7: –
• Johnson KA, Goody Station. The original Michaelis constant: conversion of the Michaelis-Menten paper. Biochemistry. ;50(39)
• Punekar NS. Henri–Michaelis–Menten Equation.

  In: ENZYMES: Catalysis, Kinetics and Mechanisms. Cow, Singapore.